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Synthetic opioid overdose deaths fell 20.7% in 2025, HHS finds

By Ella Ruder 1 min read

A drop in drug overdose deaths drove most of the 2025 decline in unintentional injury deaths, the largest single contributor to the falling U.S. death rate, according to an Oct. 27 analysis from HHS’ Office of the Assistant Secretary for Planning and Evaluation. Unintentional injuries accounted for 30% of the decline in the age-adjusted death rate between 2024 and 2025, ahead of COVID-19, cancer and heart disease. Overdoses made up about 73% of the injury decline. Nearly all of the overdose decline, about 96%, came from deaths involving fentanyl and… Originally published in Becker’s Hospital Review. Read More

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