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J&J’s Caplyta succeeds in 2nd phase 3 bipolar mania trial

By Sophie Eydis 1 min read

Caplyta, a Johnson & Johnson drug, met its primary and key secondary endpoints in a second pivotal phase 3 trial evaluating it for manic episodes in adults with bipolar I disorder. Study 452 found that Caplyta significantly reduced manic symptoms and overall illness severity compared with placebo at Week 3, with improvements observed as early as Day 3. The global, randomized, double-blind study compared once-daily Caplyta 42 mg with placebo over three weeks in adults with manic episodes, with or without mixed features. At Week 3, patients receiving Caplyta had… Originally published in Becker’s Hospital Review. Read More

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